Her study found the glymphatic clearance was mediated by a hormone called norepinephrine and happened almost exclusively during the NREM sleep phase. But it only worked when sleep was natural. Anesthesia and sleeping pills shut this process down nearly completely.
I have ADHD. Without drugs, I only sleep during the day, and sometimes, I’ll skip a day and feel like crap about it no matter what I do.
I mean without drugs. I used to be an all-natural whackadoo.
Nowadays I do drugs about it and I’m allowed to be a real human. Guess my brain will clean itself when I die.
You need healthy, natural sleep. Chew some valerian root and get more exercise.
I wonder what melatonin does
Forget melatonin, I want to know wtf cheese is doing to my brain when I sleep on it.
Charlie Kelly… who taught you about Lemmy?
Im pretty sure cat food and spray paint shut down m9re than just the NREM cycle in the brain…
Eff. I require sleeping pills. I guess I can look forward to a melted brain in old age.
What about alcohol?
Fucks you up
Then gets you really sleepy
This has been fairly well known for at least 15 years among medi-academia. But discovering the specific pathways involved leaves me (femininely) turgid
The study was only on zolpidem. IMO it can probably be generalised to other Z drugs, and possibly benzos. Drugs that work by entirely different mechanisms like melatonin and orexin antagonists could be completely different.
What about Benadryl?
The hat man cleans your brain for you.
Unknown, but it’s an anticholinergic, and those are associated with dementia.
I wonder if ketamine has the same effect, he asked apropos of nothing…
Anesthesia
yes
Actually maybe not? Iirc most “traditional” anesthesia basically knocks you down to the bare minimum of brain activity to remain alive and reliably regain consciousness (which is why being under anesthesia is usually a “blink and you miss it” ordeal, your brain isn’t active enough to be aware that time has passed).
However, if I’m not mistaken, stuff like ketamine or nitrous don’t do that, and sedate you in a manner more similar to natural sleep.
Fuck.
Now what?
That usually helps me sleep better too
Apparently the water supply in my town is dosed with sleeping pills.
Honestly, it might be. When people pee, that toilet water goes somewhere.
