After numerous injuries over the years from his energetic clowning, his health was also declining rapidly, and he retired in 1823. He appeared occasionally on stage for a few years thereafter, but his performances were restricted by his worsening physical disabilities. In his last years, Grimaldi lived in relative obscurity and became a depressed, impoverished alcoholic. He outlived both his wife and his actor son, Joseph Samuel, dying at home in Islington in 1837, aged 58.

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