Viruses like SARS-CoV-2 use sugar molecules to hide from the immune system, but scientists at Scripps Research have designed a universal coronavirus vaccine that strips these sugars and exposes a stable, rarely mutating part of the spike protein. This approach triggered strong immune responses in
The glycan camouflage is less effective once the immune system has been exposed to the spike protein, and “knows” what to look for, so it can mount a response, through the T and B cells.